CDMX /
Cellular senescence is a biological process in which cells lose their ability to divide. and function properly, contributing to aging and the development of age-related diseases.
As the cells enter this state of permanent arrest, stop fulfilling their vital functionsleading to progressive tissue dysfunction.
However, recent research is uncovering the potential of peptides to influence cellular senescence and mitigate its effects, opening new possibilities in the treatment of aging.
Various factors, such as DNA damage, telomere shortening, and oxidative stress, trigger cellular senescence. Senescent cells accumulate damage that cannot be repaired properly, which causes them to enter a state of growth arrest.
Besides, These cells release a series of proinflammatory molecules.known as the senescence-associated secretory phenotype (SASP), which can cause damage to surrounding tissues and accelerate the aging of other cells.
Peptides, small chains of amino acidsare emerging as a promising field of research to combat the effects of cellular aging.
Their ability to interact with various biological pathways makes them potential modulators of senescence. These compounds can influence cellular aging by acting on oxidative stressDNA repair and tissue regeneration.
Oxidative stress, caused by an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them, is a key factor in cellular senescence. Research suggests that certain peptides with antioxidant properties can counteract this damage, delaying the onset of senescence.
Peptides could also support the activity of endogenous antioxidant systemssuch as superoxide dismutase and catalase, thus prolonging the lifespan of cells.
DNA damage, particularly double-strand breaks, is another important trigger of senescence. Studies have shown that some peptides could promote DNA repair mechanismshelping to reduce damage accumulation and promoting genetic stability. By protecting DNA from further damage, these peptides may delay cellular aging and contribute to longevity.
The potential of peptides in cellular senescence
Additionally, it is believed that peptides can promote cell regeneration by inducing autophagy, a process that eliminates damaged cellular components. By reducing the number of senescent cells in tissues, these compounds could improve regenerative capacity of surrounding functional cells, mitigating some of the negative effects of aging.
The role of peptides in modulating cellular senescence is attracting the attention of researchers studying age-related diseases such as osteoarthritis and cardiovascular diseases. By targeting senescent cells, peptides could offer new approaches to disease modeling and the development of more effective treatments.
Although there is still much to investigate, the potential of peptides as tools to combat cellular senescence and improving longevity offers a promising avenue in the fight against aging and related diseases.
​FCA
